Marine C. Cambon

Marine C. Cambon

Postdoctoral researcher

School of Natural Sciences, Bangor Unviversity, Wales, UK

Microbial ecology and evolution

My main interest is the understanding of the multiple and complex interactions existing between a host, and its associated microorganisms. These microorganisms can either be pathogens or members of the host microbiota and potentially interact with each other. Interactions between microorganisms or with the host can vary with environmental conditions, and impact the ecology and evolution of all partners. I have been using a combination of lab experiments, field sampling and microbial community single gene profiling, on insect and plant hosts.

Interests

  • Microbial ecology and evolution
  • Host-pathogen interactions
  • Microbiota
  • Vector-borne diseases

Education

  • PhD in Evolutionary Biology, 2018

    Paul Sabatier University, Toulouse, France

  • Msc in Ecology and Evolutionary Biology, 2015

    Paul Sabatier University, Toulouse, France

  • BSc in Population and organism biology, 2013

    Paul Sabatier University, Toulouse, France

Experience

 
 
 
 
 

Postdoctoral researcher Microbial Ecology and Forest Pathology

Bangor University, James McDonald’s lab

Dec 2020 – Present Bangor, Wales, UK
Understanding Acute Oak Decline in the UK: the role of oak microbiome, environment, and interactions between bacterial pathogens and the the two-spotted oak buprestid.
 
 
 
 
 

Postdoctoral researcher

BioGeCo lab, INRAE, Bordeaux University

May 2019 – Dec 2020 Bordeaux, France
Leaf microbiota as a bioindicator of drought stress in trees: toward next-generation biomonitoring of forest ecosystems.
 
 
 
 
 

PhD Student

EDB lab, CNRS, Paul Sabatier University

Oct 2015 – Dec 2018 Toulouse, France

Heterogeneity within infections: the case of the vector-borne insect pathogen, Xenorhabdus nematophila.

In collaboration with the DGIMI lab, INRAE Montpellier University

Projects

Chemical cues responsible for pathogen virulence in Acute Oak Decline (AOD)

Acute oak decline (AOD) is a complex decline disease affecting mature oak trees, characterised by stem bleeds and inner bark necrosis, eventually leading to tree death. The tissue necrosis observed in trees with AOD is caused by a polymicrobial consortium including the bacterial species Brenneria goodwinii. This bacterium is known to express several putative virulence genes, especially in tree hosts which are invaded by the bark-boring beetle Agrilus biguttatus. Yet, the nature of this insect-bacteria interaction and its consequences for AOD pathogenesis are still to be unravelled. Using a combination of chemical and molecular microbial ecology methods, we will test the effect of secondary metabolites released by A. bigutattus and the tree host on the expression of a set of putative virulence genes in B. goodwinii. We hypothesise that the beetle itself, and/or the tree response to the beetle’s presence, produce chemical cues triggering B. goodwinii proliferation and expression of genes responsible for the establishment of host tissue necrosis.

This work is part of the BAC-STOP project.

  • Head of the project: Sandra Denman
  • Postdoc advisor: James McDonald

Next-Generation Biomonitoring of forest health

This project aims at finding bioindicators of tree drought stress using environmental DNA. We investigated the potential signature of tree water stress in leaf microbiota using single gene community profiling. We then used machine learning techniques to predict tree water stress from their leaf microbiota composition. This work is part of the ANR project NGB.

  • Head of the project: David Bohan
  • Postdoc advisor: Corinne Vacher

Heterogeneity within infections

This project addresses multiple sources of heterogeneity during a pathogenic infection. We first investigated within-host evolution of an insect pathogen (heterogeneity in the pathogen population) as well as interactions between the pathogen and the microbiota of its host (heterogeneity in the total bacterial population).

  • PhD supervisors: Jean-Baptiste Ferdy and Sophie Gaudriault

Publications

(2022). Drought tolerance traits in Neotropical trees correlate with the composition of phyllosphere fungal communities. Phytobiomes.

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(2022). Changes in fish skin microbiota along gradients of eutrophication in human-altered rivers. FEMS Microbiology Ecology.

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(2021). Coupling ecological network analysis with high-throughput sequencing-based surveys: Lessons from the next-generation biomonitoring project. Advances in Ecological Research.

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(2020). The plant endosphere world - bacterial life within plants. Environ Microbiol.

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(2020). Bacterial community profile after the lethal infection of Steinernema-Xenorhabdus pairs into soil-reared Tenebrio molitor larvae. FEMS Microbiol Ecol.

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(2019). Role of the Photorhabdus Dam methyltransferase during interactions with its invertebrate hosts. PloSOne.

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(2019). Selection of bacterial mutants in late infections: when vector transmission trades off against growth advantage in stationary phase. mBio.

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